Dissecting the Global Dynamic Molecular Profiles of Human Fetal Kidney Development by Single-Cell RNA Sequencing

To investigate the gene expression profiles of human fetal kidney development, Wang et al. performed single-cell RNA-seq for >3,000 renal cells. They highlight the heterogeneity of cap mesenchyme and regulatory factors in nephron formation. The results reveal cell-type-specific risk genes in congenital renal diseases.

为探究人类胎儿肾脏发育的基因表达谱，Wang等对逾3000个肾脏细胞开展了单细胞RNA测序（single-cell RNA-seq）。该研究着重解析了帽状间充质（cap mesenchyme）的异质性与肾单位形成过程中的调控因子，其结果揭示了先天性肾脏疾病中细胞类型特异性风险基因。