Asymmetric Total Synthesis of Kopsiyunnanine K, a Monoterpenoid Indole Alkaloid with a Rearranged Skeleton

A new monoterpenoid
indole alkaloid, kopsiyunnanine K, was isolated
from Kopsia arborea. Its intriguing
rearranged structure and absolute configuration, which were inferred
from spectral data and a possible biosynthetic pathway, were determined
on the basis of a 13-step asymmetric total synthesis.

本研究从倒披针叶狗牙花（Kopsia arborea）中分离得到一种新的单萜吲哚生物碱(monoterpenoid indole alkaloid)，命名为柯氏云南碱K（kopsiyunnanine K）。该化合物具有独特的重排骨架结构，其绝对构型先通过光谱数据与潜在生物合成途径进行推演，最终经13步不对称全合成得以确证。