The Institute of Structural and Molecular Biology (ISMB) application for beam time, comprising groups from Birkbeck College, UCL and the Que

The ISMB spans Birkbeck and UCL with researchers in the core Departments at Birkbeck Natual Sciences and several UCL Research Departments.
Research groups from Queen Mary University of London (QMUL) are joint co-applicants as they have strong links and collaborations with groups from ISMB.
All groups share common interests in disciplines including structural, chemical, molecular and cell biology; using multidisciplinary and multiscalar approaches.
ISMB, UCL and QMUL investigators, ranging from early-career research fellows to internationally-established senior academics, apply X-ray crystallography
carried out mainly at our Wellcome funded facility at Birkbeck, as an essential method enabling: i) description of the atomic level mechanistic details of macromolecules and macromolecular machines, and ii) structure-based drug discovery, iii) interdisciplinary structural biology projects mainly with cryoelectron microscopy (cryo-EM).

结构与分子生物学研究所（ISMB）的研究团队覆盖伯克贝克学院与伦敦大学学院（UCL），研究人员分别隶属于伯克贝克学院自然科学系核心部门，以及伦敦大学学院的多个研究院系。
伦敦大学玛丽皇后学院（QMUL）的多个研究团队作为联合共同申请人参与本项目，因其与结构与分子生物学研究所的研究团队存在紧密的联系与合作关系。
所有参与团队的研究方向均涵盖结构生物学、化学、分子生物学与细胞生物学等学科，并采用多学科、多尺度的研究方法。
结构与分子生物学研究所、伦敦大学学院以及伦敦大学玛丽皇后学院的研究人员，涵盖从早期职业研究员到国际知名资深学者的全梯队，主要依托伯克贝克学院内由惠康基金资助的实验平台开展X射线晶体学研究。该方法作为核心技术手段，可实现三大目标：其一，阐明大分子及大分子机器的原子级作用机制细节；其二，开展基于结构的药物发现研究；其三，主要结合冷冻电子显微镜（cryo-EM）开展跨学科结构生物学项目。