Sequencing of Cervical Cancer

Precision mapping of genetic alterations in cancer can enable better selection of therapies and improved outcomes when combined with new sequencing diagnostics. We describe whole-exome sequences from cervical adenocarcinomas and paired normal samples in Hong Kong Chinese women. These data uncover a heterogeneous genomic landscape but identify commonly aberrant loci including FAT1, ARID1A, ERBB2 and PIK3CA that may provide a focus for the development of individualized targeted therapies for Chinese women with cervical adenocarcinoma.]]>
Precision mapping of genetic alterations in cancer can enable better selection of therapies and improved outcomes when combined with new sequencing diagnostics. We describe whole-exome sequences from cervical adenocarcinomas and paired normal samples in Hong Kong Chinese women. These data uncover a heterogeneous genomic landscape but identify commonly aberrant loci including FAT1, ARID1A, ERBB2 and PIK3CA that may provide a focus for the development of individualized targeted therapies for Chinese women with cervical adenocarcinoma.]]>

癌症遗传变异的精准图谱绘制，联合新型测序诊断技术，可助力更精准的治疗方案选择，改善患者预后。本研究公开了香港华裔女性宫颈腺癌患者及其配对正常样本的全外显子组测序（whole-exome sequencing）数据。该数据集揭示了宫颈腺癌的异质性基因组特征，并鉴定出FAT1、ARID1A、ERBB2及PIK3CA等常见异常位点，可为宫颈腺癌华裔女性的个体化靶向治疗研发提供关键靶点。
癌症遗传变异的精准图谱绘制，联合新型测序诊断技术，可助力更精准的治疗方案选择，改善患者预后。本研究公开了香港华裔女性宫颈腺癌患者及其配对正常样本的全外显子组测序（whole-exome sequencing）数据。该数据集揭示了宫颈腺癌的异质性基因组特征，并鉴定出FAT1、ARID1A、ERBB2及PIK3CA等常见异常位点，可为宫颈腺癌华裔女性的个体化靶向治疗研发提供关键靶点。