Detect circulating miRNA Expression change after exposure to hexavalent chromium (an carcinogen) among occuaptional workers

We profiled plasma miRNA expression in workers exposed to Cr(VI), and assessed genetic damage on chromosome and DNA to compare the sensitivity between epigenetic changes and genetic damage for biomarkers We screened differently expressed plasma miRNAs between high and low Cr(VI) exposed workers using Agilent miRNA microarray. low exposure : <5.49 ng/ml; high exposure >5.49 ng/ml

本研究对六价铬[Cr(VI)]暴露工人的血浆微小RNA（miRNA）表达谱进行了分析，并评估了染色体与DNA水平的遗传损伤，以比较表观遗传改变与遗传损伤作为生物标志物的灵敏度。
本研究采用安捷伦（Agilent）miRNA微阵列芯片，筛选了高低六价铬暴露组工人的血浆差异表达miRNA。
暴露分组标准为：低暴露组<5.49 ng/ml，高暴露组>5.49 ng/ml