Expression data from iMyc mouse B lymphoma and human DLBCL. Expression data from iMyc mouse B lymphoma and human DLBCL

Cross-species comparative gene expression profiling was performed to identify differentially expressed genes conserved in aggressive B lymphomas. Overall design: Whole genome expression arrays from mouse B220+ splenic B cells (wild-type C57BL/6, B6) were compared to whole tumors (approximately >75% neoplastic cells) from B6.iMyc mice. Correspondingly, isolated human peripheral blood B cells were compared to human diffuse large B cell (DLBCL) whole tumors (approximately >75% neoplastic cells) DLBCL.

本研究通过跨物种比较基因表达谱分析（cross-species comparative gene expression profiling），旨在鉴定侵袭性B细胞淋巴瘤中保守存在的差异表达基因。实验设计：将野生型C57BL/6（B6）小鼠的B220阳性脾脏B细胞的全基因组表达芯片数据，与B6.iMyc小鼠的实体瘤（瘤细胞占比约＞75%）的全基因组表达芯片数据进行对比；相应地，将分离得到的人外周血B细胞与人类弥漫大B细胞淋巴瘤（diffuse large B cell lymphoma, DLBCL）实体瘤（瘤细胞占比约＞75%）的全基因组表达芯片数据进行对比。