WP2881 - Estrogen receptor pathway - Homo sapiens

The estrogen receptor is a nuclear receptor that is activated upon ligand binding and subsequently translocates to the nuclear. There, it activates transcription of target genes involved in essential cellular processes. The ER receptor has been implicated in a multitude of diseases, most notably cancer (breast/ovarian).

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2881).

雌激素受体（estrogen receptor, ER）是一种核受体，可在配体结合后被激活，随后转位至细胞核内。在此处，它能够激活参与核心细胞生命过程的靶基因的转录。该受体已被证实与众多疾病存在关联，其中尤以癌症（乳腺癌/卵巢癌）最为突出。

本通路中的蛋白质可通过[CPTAC检测门户（CPTAC Assay Portal）](https://assays.cancer.gov/available_assays?wp_id=WP2881)获取对应的靶向检测服务。