Data Sheet 2_Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis.docx

AimThis study aims to examine the comparative risk of obesity in the FTO rs9939609 genotype in multiethnic groups in Asia, considering that obesity has become a global disease.
Data synthesisData searches were carried out in several electronic databases: PubMed, Scopus, Google Scholar, ScienceDirect, ClinicalTrials.gov and NCBI. The search involved a combination of keywords related to genetics and obesity risk. Pooled Odds Ratio (POR) with 95% CI was calculated based on the pooled data. Review Manager (RevMan) 5.4.1 were used to analyze the data.
ResultsFrom 18 studies, the results of the dominant genetic model AA vs. TT showed POR 95%Cl = 1.95 (1.36–2.80); p < 0.00001, in AA vs. TA genetic recessive model, POR 95%Cl =1.31 (1.07–1.60); p = 0.002, then the final model of TA vs. TT codominance genetic model obtained POR 95%Cl = 1.52 (1.04–2.23); p < 0.00001. The overall risk of bias was low.
ConclusionFrom this research, it was found that there was a comparison of the genotype that had a higher risk of obesity, namely the AA genotype in multiethnic groups in Asia.
Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=546434.

研究目的：鉴于肥胖已成为全球性疾病，本研究旨在探讨亚洲多民族人群中FTO rs9939609基因型与肥胖发生风险的比较差异。
资料合成：本研究在PubMed、Scopus、Google Scholar、ScienceDirect、ClinicalTrials.gov及NCBI等多个电子数据库中开展文献检索，检索策略结合了与遗传学及肥胖风险相关的关键词组合。基于合并后的研究数据，计算合并比值比（Pooled Odds Ratio, POR）及其95%置信区间（95% CI），并采用Review Manager (RevMan) 5.4.1软件进行数据分析。
研究结果：本研究共纳入18项相关研究，结果显示：在显性遗传模型（AA vs. TT）中，合并比值比及95%置信区间为1.95（1.36~2.80），p<0.00001；在隐性遗传模型（AA vs. TA）中，合并比值比及95%置信区间为1.31（1.07~1.60），p=0.002；在共显性遗传模型（TA vs. TT）中，合并比值比及95%置信区间为1.52（1.04~2.23），p<0.00001。本研究整体偏倚风险较低。
研究结论：本研究发现，在亚洲多民族人群中，AA基因型为肥胖发生风险较高的基因型。
系统评价注册：https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=546434