CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH C1=CN(N=C(C1=O)c2ccnn2c3ccc(cc3F)F)c4cc(ccc4)OC(F)(F)F, micromolar IC50=0.041355

Protein Data Bank Japan2024-10-16 更新2026-03-21 收录

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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH C1=CN(N=C(C1=O)c2ccnn2c3ccc(cc3F)F)c4cc(ccc4)OC(F)(F)F, micromolar IC50=0.041355 Descriptor: 3-[1-(2,4-difluorophenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethoxy)phenyl]pyridazin-4(1H)-one, CHLORIDE ION, GLYCEROL, ... Authors: Joseph, C, Benz, J, Flohr, A, Rogers-Evans, M, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published

人源磷酸二酯酶10与配体C1=CN(N=C(C1=O)c2ccnn2c3ccc(cc3F)F)c4cc(ccc4)OC(F)(F)F复合物的晶体结构，该配体的半数抑制浓度（IC50）为微摩尔级，数值为0.041355。描述符：3-[1-(2,4-二氟苯基)-1H-吡唑-5-基]-1-[3-(三氟甲氧基)苯基]哒嗪-4(1H)-酮、氯离子、甘油等。作者：Joseph C、Benz J、Flohr A、Rogers-Evans M、Rudolph M.G.。入库日期：2022-02-01，发布日期：2022-10-12，最后修改日期：2024-10-16。实验方法：X射线衍射（分辨率2.1埃）。引用文献：《人源磷酸二酯酶10复合物晶体结构》，待发表

创建时间：

2022-02-01