Table_4_The increasing incidence and high body mass index-related burden of gallbladder and biliary diseases–A results from global burden of disease study 2019.pdf

BackgroundGallbladder and biliary diseases are common gastrointestinal conditions associated with huge socioeconomic costs and are considered risk factors for cardiovascular diseases and digestive system cancers. The prevalence and incidence of gallbladder and biliary diseases have not received enough attention from 1990 to 2019. Several non-communicable diseases were associated with the incidence of gallbladder and biliary diseases. It is necessary to clarify the change in the incidence and disability burden of gallbladder and biliary diseases worldwide.
MethodsData on high body mass index (BMI)-related disease burden and incidence, years of life lost prematurely, and years lived with disability (YLDs) due to gallbladder and biliary diseases were obtained from the Global Burden of Disease 2019. The estimated annual percentage change was calculated to qualify the gallbladder and biliary disease burden change.
ResultsThe global age-standardized incidence rate has increased from 585.35 per 100,000 (95% UI: 506.05–679.86) in 1990 to 634.32 per 100,000 (95% UI: 540.21–742.93) in 2019. And the increase in incidence was positively correlated with rising high BMI-related summary exposure value. The high BMI-related YLDs of gallbladder and biliary diseases have increased worldwide over time. Globally, the 25–49 age group suffered a rapid rise in incidence and high BMI attributable to the YLDs rate of gallbladder and biliary diseases.
ConclusionThe global incidence and high BMI-related YLDs of gallbladder and biliary diseases remain prominent to increase over the past 30 years. Notably, the incidence and high BMI-related YLDs among people aged 25–49 years have rapidly increased over time. Therefore, high BMI should be emphasized in strategic priorities for controlling gallbladder and biliary diseases.

研究背景
胆囊与胆道疾病（Gallbladder and biliary diseases）是一类常见的胃肠道疾病，不仅伴随高额社会经济成本，同时也是心血管疾病与消化系统癌症的危险因素。1990年至2019年间，胆囊与胆道疾病的患病率与发病率尚未得到足够重视。多项研究表明，多种非传染性疾病与胆囊与胆道疾病的发病风险相关，明确全球范围内胆囊与胆道疾病的发病率与伤残负担变化情况具有重要意义。

研究方法
本研究获取的数据涵盖高身体质量指数（Body Mass Index, BMI）相关的疾病负担与发病数据、因胆囊与胆道疾病所致的过早死亡损失寿命年（Years of Life Lost Prematurely, YLL）与伤残损失寿命年（Years Lived with Disability, YLDs），所有数据均取自《2019年全球疾病负担研究》（Global Burden of Disease 2019）。通过计算估计年度百分比变化（Estimated Annual Percentage Change, EAPC）以量化胆囊与胆道疾病负担的变化趋势。

研究结果
全球年龄标化发病率已从1990年的585.35/10万（95%置信区间：506.05~679.86）升至2019年的634.32/10万（95%置信区间：540.21~742.93）。发病率的升高与高BMI相关综合暴露值的上升呈正相关。全球范围内，与高BMI相关的胆囊与胆道疾病伤残损失寿命年随时间推移均有所增加。此外，25~49岁年龄组的胆囊与胆道疾病发病率以及高BMI归因的伤残损失寿命年率均出现快速升高。

研究结论
过去30年间，全球胆囊与胆道疾病的发病率以及与高BMI相关的伤残损失寿命年仍呈显著上升趋势。值得注意的是，25~49岁人群的该病发病率与高BMI相关伤残损失寿命年随时间推移快速升高。因此，在胆囊与胆道疾病防控的战略优先级制定中，应将高身体质量指数作为重点关注的危险因素。