Cholinergic modulation of motor sequence learning

The cholinergic system plays a key role in motor function, but whether pharmacological modulation of cholinergic activity affects motor sequence learning is unknown. The acetylcholine recepter antagonist biperiden, an established treatment in movement disorder, reduces attentional modulation, but whether it influences motor sequence learning is not clear. Using a randomized, double-blind placebo-controlled crossover design, we tested thirty healthy young participants and show that biperiden impairs the ability to learn sequential finger movements, accompanied by widespread oscillatory broadband power changes (4-25 Hz) in the motor sequence learning network after receiving biperiden, with greater power in the theta, alpha, and beta bands over ipsilateral motor and bilateral parietal–occipital areas. These findings highlight the role of cholinergic processes in motor sequence learning.Behavioral data (mean normalized learning score, reaction time difference, fatigue) for each participant, depending on condition (biperiden, placebo).Cluster-based permutation test results for the main effect sequence type (repeated, random), condition (biperiden, placebo), and their interaction and corresponding grand-average event-related spectral perturbations.

胆碱能系统（cholinergic system）在运动功能中发挥关键作用，但胆碱能活动的药理学调控是否会影响运动序列学习目前仍不明确。乙酰胆碱受体拮抗剂（acetylcholine receptor antagonist）比哌立登（biperiden）是已获批的运动障碍治疗药物，可减弱注意调控效应，但其是否会影响运动序列学习尚未明晰。本研究采用随机双盲安慰剂交叉对照设计，招募30名健康青年受试者开展实验，结果显示比哌立登会损害受试者的序列手指运动学习能力，伴随给药后运动序列学习网络内广泛的4-25 Hz振荡宽带功率变化，且在同侧运动皮层及双侧顶枕区的θ、α与β频段功率显著升高。上述研究结果凸显了胆碱能过程在运动序列学习中的作用。本数据集包含每位受试者在两种实验条件（比哌立登给药组、安慰剂组）下的行为学数据，具体包括标准化平均学习得分、反应时差值、疲劳度指标。同时包含基于聚类置换检验的结果，涵盖序列类型（重复序列、随机序列）、实验条件（比哌立登、安慰剂）的主效应及其交互效应，以及对应的总平均事件相关谱扰动（event-related spectral perturbations）数据。