Activity and cytotoxicity of HDAC inhibitors in the in vitro HIV latency model.

Latently infected primary CD4 T cells prepared from three independent healthy donors were treated with the indicated compounds continuously for 48 hours. EC50 and CC50 values were determined from each dose-dependent response using a multi-parameter algorithm. Data are mean ± SD from three independent experiments performed in quadruplicate.

从三名独立健康供体中分离制备的潜伏感染原代CD4阳性T细胞，使用指定化合物持续处理48小时。采用多参数算法，通过各剂量依赖性反应测定得到半数效应浓度（EC50）与半数细胞毒性浓度（CC50）数值。实验数据为三次独立实验（每次均设置四个复孔）所得的平均值±标准差。