Phenotypic resources immortalized in a panel of wild-derived strains of five species of house mice

The house mouse, Mus musculus, is a widely used animal model in biomedical research, with classical laboratory strains (CLS) being the most frequently employed. However, the limited genetic variability in CLS hinders their applicability in evolutionary studies. Wild-derived strains (WDS), on the other hand, provide a suitable resource for such investigations. To assess the proportion of variation added by wild progenitors, we estimated phenotypic variation in 84 WDS representing 5 species (M. musculus, M. spretus, M. spicilegus, M. macedonicus, M. caroli), 3 subspecies (M. m. musculus, M. m. domesticus, M. m. castaneus), and compared it with 5 CLS. The spectrum of WDS captures long-term mouse evolution, estimated to be over 5 million years ago since the split of M. caroli from the remaining mouse species. All mice are housed in a conventional breeding facility (without a nanofilter barrier or specific-pathogen free condition) at the Institute of Vertebrate Biology, Czech Academy of Scie..., The measures presented in four csv files were obtained from fresh mice immediately after sacrifice, and the units of variables are specified as millimeters (mm) for length measures and grams for mass measures., , # Data from: Phenotypic resources immortalized in a panel of wild-derived strains of five species of house mice

\[[https://doi.org/10.5061/dryad.r7sqv9skn](https://doi.org/10.5061/dryad.r7sqv9skn)]

The dataset comprises four distinct datasets as detailed below:

### Dataset 1: Datatset\_1. Morphology.Males.csv

Contains raw morphometric data of 2284 male mice with columns:
“Genome” = Taxonomic status of the strain where mus = M. m. musculus, dom = M. m. domesticus, CLS = classical lab strain with predominantly M. m. domesticus genome, cas = M. m. castaneus, car = M. caroli, spi = M. spicilegus, spr = M. spretus, mac = M. macedonicus
“Strain” = wild-derived strain code
“PIN” = identification code of the mouse
“BW” = Body weight (g)
“L” = Body length (mm)
“LCd” = Tail length (mm)
“Tmass” = Mean testis weight (g)
“Epidydimis” = Weight of the left epidydimis (g)
“SemVes” = Weight of seminal vesicles (g)
“Sperm” = Number of sperm (millions)
“Tail.Body” = 100*Tail length/Body length

### Da...

家鼠（Mus musculus）是生物医学研究中应用广泛的动物模型，其中经典实验室品系（classical laboratory strains, CLS）最为常用。然而，CLS有限的遗传多样性制约了其在进化研究中的适用性。相较之下，野生来源品系（wild-derived strains, WDS）为这类研究提供了理想的实验资源。为评估野生祖先所贡献的变异比例，我们对覆盖5个物种、3个亚种的84个WDS进行了表型变异评估，并与5个CLS进行对比。本次研究涉及的5个物种包括小家鼠（Mus musculus）、喷小家鼠（M. spretus）、粪小家鼠（M. spicilegus）、马其顿小家鼠（M. macedonicus）以及卡氏小家鼠（M. caroli）；3个亚种分别为蒙古亚种（M. m. musculus）、家鼠亚种（M. m. domesticus）以及亚洲亚种（M. m. castaneus）。该WDS的变异谱涵盖了卡氏小家鼠与其余小家鼠类群分化以来超过500万年的长期小鼠进化历程。所有实验小鼠均饲养于捷克科学院脊椎动物研究所的常规繁育设施内，未设置纳米过滤屏障或无特定病原体（specific-pathogen free, SPF）饲养条件。

本数据集的四项测量数据均存储于四个CSV格式文件中，取自处死后即刻的新鲜小鼠；其中长度类测量指标的单位为毫米（mm），质量类指标的单位为克（g）。

# 数据来源：源自5个小家鼠物种的野生来源品系组中永久保存的表型资源
[https://doi.org/10.5061/dryad.r7sqv9skn]

本数据集包含四个独立子数据集，详情如下：
### 子数据集1：Dataset_1. Morphology.Males.csv
包含2284只雄性小鼠的原始形态测量数据，各列含义如下：
"Genome"：品系的分类学背景，其中mus代表蒙古亚种M. m. musculus，dom代表家鼠亚种M. m. domesticus，CLS代表以家鼠亚种基因组为主的经典实验室品系，cas代表亚洲亚种M. m. castaneus，car代表卡氏小家鼠M. caroli，spi代表粪小家鼠M. spicilegus，spr代表喷小家鼠M. spretus，mac代表马其顿小家鼠M. macedonicus
"Strain"：野生来源品系代码
"PIN"：小鼠识别码
"BW"：体质量（g）
"L"：体长度（mm）
"LCd"：尾长度（mm）
"Tmass"：平均睾丸质量（g）
"Epidydimis"：左侧附睾质量（g）
"SemVes"：精囊质量（g）
"Sperm"：精子数量（百万）
"Tail.Body"：100*尾长/体长