Biologic parameters for modeling of the CD4+ T lymphocyte compartment.

The parameters utilize for modeling CD4+ T lymphocyte turnover and infection using the NPP assumption are listed. For the PP assumption, activated cells were committed to 8 divisions with the same kinetics as CTLs (see Table 2).*Derived constant based on biologically observed steady state value and estimated loss rate of activated cells (see Supplemental Methods). For the programmed proliferation assumption (PP), the value is 1.9×10−4/day.**Derived constant based on biologically observed steady state value and estimated loss rate of total body CD4+ T lymphocytes (see Supplemental Methods). For the programmed proliferation assumption (PP), the value is 2.5×106/day.***Set constant based on the model yielding timing of peak viremia corresponding to biologically observed timing, and consistent with virion viability ranging from 1∶1 to 1∶1000 [64] and Virion Prod.

本研究列出了采用非程序化增殖假设（Non-Programmed Proliferation, NPP）构建CD4+ T淋巴细胞周转与感染模型所用的全部参数。针对程序化增殖假设（Programmed Proliferation, PP），活化细胞将以与细胞毒性T淋巴细胞（Cytotoxic T Lymphocyte, CTL）一致的动力学特性完成8次分裂，具体详见表2。* 该衍生常数基于实验观测的稳态值与活化细胞的估算丢失率推导所得（详见补充方法）。针对程序化增殖假设（PP），其取值为1.9×10⁻⁴/天。** 该衍生常数基于实验观测的全身CD4+ T淋巴细胞稳态值与估算丢失率推导所得（详见补充方法）。针对程序化增殖假设（PP），其取值为2.5×10⁶/天。*** 该设定常数由模型得到的病毒血症峰值时间确定，该时间与实验观测结果相符，且符合病毒粒子存活率介于1:1至1:1000的范围[64]及病毒粒子生成（Virion Prod.）相关设定。