The frequency of PD-1-expressing Treg cells correlates with markers of disease progression.

(A) Representative flow cytometry dot plots showing PD-1 gating on Treg cells (including eTreg and rTreg). One HIV-infected individual from each study group is displayed. Numbers indicate the percentage of PD-1+ Treg cells in PD-1 stained samples (down) compared with isotype control antibodies (up). (B) PD-1 expression on Treg cells from different HIV-infected study groups (black circles) and healthy controls (empty triangles) are shown as indicated. Each dot represents the result from one individual. The mean ± SEM (standard error of the mean) is shown. Significant differences were determined by a Mann-Whitney U test, corrected for multiple comparisons using Bonferroni method, and indicated by asterisks (*p

(A) 代表性流式细胞术散点图展示了调节性T细胞（regulatory T cells, Treg，包含效应性调节性T细胞（effector Treg, eTreg）与静息调节性T细胞（resting Treg, rTreg））的PD-1（Programmed Death 1）门控分析。本图展示了每个研究组中1名人类免疫缺陷病毒（Human Immunodeficiency Virus, HIV）感染者的检测结果。图中数值代表PD-1染色样本（下方）中PD-1阳性Treg细胞的占比，以同型对照抗体组（上方）作为参照。(B) 展示了不同HIV感染研究组（黑色圆点）与健康对照（空心三角）的Treg细胞表面PD-1表达水平。每个圆点代表1名个体的检测结果，图中呈现了均值±标准误（standard error of the mean, SEM）。组间显著性差异通过曼-惠特尼U检验（Mann-Whitney U test）确定，并采用邦费罗尼法（Bonferroni method）校正多重比较，以星号标注显著性差异（*p ）