Guajavadimer A, a Dimeric Caryophyllene-Derived Meroterpenoid with a New Carbon Skeleton from the Leaves of Psidium guajava

Guajavadimer A (1), a dimeric sesquiterpene-based meroterpenoid which possessed an unprecedented two caryophyllenes, a benzylphlorogulcinol, and a flavonone-fused complicated stereochemical skeleton, was isolated from the leaves of Psidium guajava L. Its structure and absolute configuration were elucidated on the basis of spectroscopic data and X-ray crystallography. Guajavadimer A (1) showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells.

番石榴二聚体A（1）（Guajavadimer A (1)）是一类基于倍半萜的二聚型杂萜（meroterpenoid），其具有前所未有的两个石竹烯（caryophyllene）单元、一个苄基间苯三酚（benzylphlorogulcinol）以及黄烷酮（flavonone）稠合的复杂立体化学骨架，该化合物从番石榴（Psidium guajava L.）的叶片中分离得到。其结构与绝对构型通过光谱数据及X射线晶体衍射分析得以阐明。番石榴二聚体A（1）在对乙酰氨基酚（N-acetyl-p-aminophenol, APAP）诱导的HepG2细胞毒性模型中表现出中等强度的保肝活性。