Significant associations of TRPV1 variants and somatosensory function.

Significant associations of selected TRPV1 variants with three parameters of quantitative sensory testing (CDT, cold detection threshold, HPT, heat pain threshold, MDT, mechanical detection threshold) in 121 patients belonging to cluster 1. Z-score means of each QST parameter were correlated with genotypes applying a dominant or recessive model.1ANOVA test,2t-test.

在属于聚类1的121例患者中，所筛选出的瞬态受体电位阳离子通道亚家族V成员1 (TRPV1) 变异体与定量感觉测试 (quantitative sensory testing, QST) 的三项参数存在显著关联，这三项参数分别为冷检测阈值 (cold detection threshold, CDT)、热痛阈值 (heat pain threshold, HPT) 以及机械检测阈值 (mechanical detection threshold, MDT)。研究采用显性或隐性遗传模型，将每项QST参数的Z评分均值与基因型进行相关性分析。1 方差分析检验 (ANOVA test)；2 t检验。