Single cell RNA sequencing of MPN patients from humans in South Korea

we analyzed BM aspirates in reactive BMs, pre-PMFs, overt PMFs, and non-PMF MPNs by single-cell RNA sequencing (scRNA-seq), identifying cell types , including hematopoietic stem and progenitor cell (HSPC) and MK.

我们通过单细胞RNA测序（scRNA-seq）分析了反应性骨髓、原发性骨髓纤维化前期、显性原发性骨髓纤维化以及非原发性骨髓纤维化的骨髓增殖性肿瘤患者的骨髓抽吸物，鉴定出包括造血干祖细胞（HSPC）与巨核细胞（MK）在内的多种细胞类型。