Treatment with commonly used antiretroviral drugs induces a type I/III interferon signature in the gut in the absence of HIV infection: Proteomics from MTN017

The purpose of this data set was to measure how the expression of proteins in rectal biopsies is affected by use of oral tenofovir disoproxil fumarate/emtricitabine for prevention of HIV infection. Proteins were measured by mass spectrometry from samples taken from the MTN-017 study at baseline and after two months of daily oral tenofovir disoproxil fumarate/emtricitabine. <br>In the raw_data tab, each row is a sample. There are several columns describing each sample and then many columns containing the expression level for each detected protein. Expression levels were adjusted for batch effects using ComBat. <br>In the protein_lookup tab, there is one row per protein detected, mapping from UniProt ID to gene symbol and Entrez Gene ID. <br>The complete methods and results are described here: https://doi.org/10.1101/701961

本数据集旨在评估口服富马酸替诺福韦二吡呋酯/恩曲他滨（tenofovir disoproxil fumarate/emtricitabine）用于人类免疫缺陷病毒（HIV）感染预防时，对直肠活检组织中蛋白质表达的影响。研究样本取自MTN-017研究，分别于基线期与每日口服该药物两个月后采集，通过质谱法（mass spectrometry）检测蛋白质表达水平。<br>在raw_data标签页中，每一行对应一个样本，包含若干描述样本属性的列，以及多列分别记录各检测到蛋白质的表达量。所有表达量已通过ComBat算法校正批次效应。<br>在protein_lookup标签页中，每一行对应一个检测到的蛋白质，实现了UniProt ID与基因符号、Entrez Gene ID的映射关联。<br>完整的研究方法与结果可参见：https://doi.org/10.1101/701961