C11orf52 as a new regulator of nanomechanical properties and cell migration in prostate cancer cells

In this study, puncture biopsies samples of patients with benign prostatic hyperplasia (BPH), medium-risk and high-risk prostate cancer were collected for RNA-seq analysis. GO analysis showed that DEGs in the medium and high risk groups were significantly enriched in processes such as extracellular region and cell motility and migration. In addition, the BPH and medium-risk groups were significantly enriched in processes such as extracellular region, developmental process and ion transport. The BPH and high-risk groups were significantly enriched in processes such as extracellular region, cell motility, migration and immune system process. In this study, differentially expressed genes associated with risk classes were identified. Differentially expressed genes between benign prostatic hyperplasia, medium-risk, and high-risk prostatic carcinoma tissues

本研究采集了良性前列腺增生（benign prostatic hyperplasia, BPH）、中危及高危前列腺癌患者的穿刺活检样本，用于RNA测序（RNA-seq）分析。GO分析结果显示，中危与高危组的差异表达基因（differentially expressed genes, DEGs）显著富集于细胞外区域、细胞运动与迁移等生物学过程。此外，良性前列腺增生（BPH）与中危组的差异表达基因显著富集于细胞外区域、发育过程及离子转运等生物学过程。而良性前列腺增生（BPH）与高危组的差异表达基因则显著富集于细胞外区域、细胞运动、迁移及免疫系统过程等生物学过程。本研究鉴定出了与风险分级相关的差异表达基因。针对良性前列腺增生、中危及高危前列腺癌组织之间的差异表达基因