Supplementary Material for: Helicobacter Pylori Infection Is not Associated with Nonalcoholic Fatty Liver Disease: A Two-year Cohort Study

Introduction: Previous studies reported inconsistent results of the association between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD).
Methods: A cohort study of 2063 adults without NAFLD at baseline, who participated in a repeated health check-up including a 13C urea breath test and abdominal ultrasonography, was conducted to evaluate the link between H. pylori infection and NAFLD development.
Results: During a mean follow-up period of 1.7 years, we did not found a significant association between H. pylori infection and NAFLD (Hazard ratio (HR) = 1.10 (0.86, 1.40), p = 0.4689). We also found that higher age, body mass index (BMI), systolic blood pressure (systolic BP), diastolic blood pressure (diastolic BP), fasting blood glucose, triglycerides, total cholesterol, low density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were risk factors, and high density lipoprotein cholesterol (HDL-C) was a protective factor for NAFLD development.
Conclusions: H. pylori infection might not be positively related to NAFLD development.

引言：既往研究针对幽门螺杆菌 (Helicobacter pylori, H. pylori) 感染与非酒精性脂肪性肝病 (nonalcoholic fatty liver disease, NAFLD) 之间的关联所得结论并不一致。
方法：本研究开展了一项队列研究，纳入2063名基线时无NAFLD的成人受试者，所有受试者均接受了包含13C尿素呼气试验与腹部超声检查在内的重复健康体检，旨在评估幽门螺杆菌感染与NAFLD发生之间的关联。
结果：平均随访时长为1.7年期间，未发现幽门螺杆菌感染与NAFLD存在显著关联 (风险比 (HR) = 1.10, 95%置信区间为0.86~1.40, P=0.4689)。本研究同时发现，年龄增大、体质量指数 (body mass index, BMI)、收缩压 (systolic BP)、舒张压 (diastolic BP)、空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇 (low density lipoprotein cholesterol, LDL-C)、丙氨酸氨基转移酶 (alanine aminotransferase, ALT) 以及天冬氨酸氨基转移酶 (aspartate aminotransferase, AST) 升高均为NAFLD发生的危险因素；而高密度脂蛋白胆固醇 (high density lipoprotein cholesterol, HDL-C) 则为NAFLD发生的保护因素。
结论：幽门螺杆菌感染可能与NAFLD的发生并无正向关联。