Gene-expression differences in peripheral blood between lithium responders and non-responders in the “Lithium Treatment -Moderate dose Use Study” (LiTMUS)

Analysis of gene-expression changes in treatment responders vs non-responders to two different treatments among subjectrs participating in LiTMUS. Results provide information on pathways that may be involved in the clinical response to Lithium in patients with bipolar disorder. Total RNA isolated from PAXgene blood RNA tubes from 60 subjects with bipolar disorder, randomized to 2 treatment groups (OPT, Li+OPT) at 2 time-points (baseline, 1 month after treatment)

本数据集针对参与LiTMUS研究的双相情感障碍受试者，分析其接受两种不同治疗方案后，治疗应答者与无应答者的基因表达变化情况。本研究结果可为阐明锂剂（Lithium）治疗双相情感障碍的临床应答相关通路提供参考依据。本研究纳入60名双相情感障碍受试者，采用PAXgene血液RNA采血管（PAXgene blood RNA tubes）采集血液并分离总RNA；所有受试者被随机分为OPT组与Li+OPT组两个治疗组，并分别在基线、治疗后1个月两个时间点完成样本采集。