Structural Biology BAG - Portugal

The Portuguese MX BAG includes 13 PIs from three different institutions. Our research interests include soluble and membrane proteins of biomedical interest from humans or pathogenic organisms, several of which can be drug targets. Focus is also given to structural enzymology, aimed at the elucidation of reaction mechanisms, active sites, and inhibition tolerance in proteins with potential biotechnology applications. In several cases, complementary structural biology approaches are being used, combining MX with SAXS and, more recently, CryoEM.

葡萄牙MX BAG包含来自3家不同机构的13名首席研究员（Principal Investigators，PIs）。我们的研究兴趣涵盖人类或病原生物中具有生物医学意义的可溶性与膜蛋白，其中若干蛋白可作为药物靶点。研究重点还包括结构酶学（structural enzymology），旨在阐明具有潜在生物技术应用价值的蛋白质的反应机制、活性位点及抑制耐受性。在多个案例中，研究人员正采用互补性结构生物学方法，将MX与小角X射线散射（SAXS）相结合，且近期更纳入了冷冻电子显微镜（CryoEM）技术。