Gene expression of abnormal uric acid synthesis animal model of silk worm Bombyx mori.. Bombyx mori

Uric acid (UA) is the final product of purine metabolism and plays an important role as a physiological antioxidant. In recent years, several different groups have reported a correlation between decreased UA in Parkinson’s disease (PD) and clinical progression and stage of PD. However, little is known about the molecular mechanisms of decreased UA under oxidative stress. We used our systematic functional annotation pipeline for silkworm genes to identify a novel UA metabolic pathway regulator under oxidative stress in a UA metabolism mutant silkworm Bombyx mori model. Overall design: Gene expression was measured in 3day of fifth instar larvae of abnormal uric acid synthesis Bombyx mori mutant of op.

尿酸（Uric acid, UA）是嘌呤代谢的终产物，作为生理性抗氧化剂发挥重要功能。近年来，多个不同研究团队相继报道帕金森病（Parkinson’s disease, PD）患者体内尿酸水平降低与疾病临床进展及分期存在显著关联。然而，目前学界对氧化应激状态下尿酸水平降低的分子机制仍所知甚少。本研究依托针对家蚕基因的系统性功能注释流程，在尿酸代谢突变的家蚕（Bombyx mori）模型中，鉴定得到氧化应激条件下全新的尿酸代谢通路调控因子。整体实验设计：以op突变的尿酸合成异常家蚕为材料，检测其5龄第3天幼虫的基因表达水平。