A multi-model transcriptome atlas of skeletal muscle atrophy in mouse models

This dataset accompanies the research article entitled "Multi-model transcriptome atlas identifies conserved and model-specific transcriptomic signatures in skeletal muscle atrophy". It comprises a comprehensive collection of integrated transcriptomic data from 42 cohorts across 26 publicly available datasets, investigating seven canonical mouse models, including aging, Cancer Cachexia, Denervation (DEN), Dexamethasone (DEX), Diabetes, Hindlimb Unloading (HU), Immobilization (IMM), of skeletal muscle atrophy.

本数据集配套于题为《多模型转录组图谱揭示骨骼肌萎缩中保守与模型特异性转录组特征》的研究论文。该数据集收录了来自26个公开数据集的42个队列的整合转录组数据，用于研究骨骼肌萎缩相关的7种经典小鼠模型，包括衰老、癌症恶病质（Cancer Cachexia）、去神经支配（Denervation, DEN）、地塞米松（Dexamethasone, DEX）、糖尿病、后肢悬吊（Hindlimb Unloading, HU）与制动（Immobilization, IMM）。