Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation

Migrasomes are recently identified vesicular organelles that form on retraction fibers behind migrating cells, cellular contents are released from migrasome by a process named migracytosis. The function of migrasomes in living organisms is unknown. Here we show that migrasomes are formed during zebrafish gastrulation, signaling molecules such as chemokines are enriched in migrasomes. Migrasomes are clustered on spatially restricted area in embryo where they provide regional cues for organ morphogenesis. Our study shown migrasome is signaling organelles which integrate spatial and specific biochemical information to coordinate migrating cells in complex biological processes such as morphogenesis.

迁移体（migrasome）是近年被发现的囊状细胞器，于迁移细胞后方的收缩纤维上生成，细胞内容物可通过名为迁移胞吐（migracytosis）的过程从迁移体中释放。目前学界对迁移体在活体内的功能仍不明晰。本研究发现，迁移体形成于斑马鱼原肠胚期，且趋化因子等信号分子在迁移体中富集。迁移体聚集于胚胎内的特定空间区域，为器官形态发生提供区域性信号指引。本研究证实，迁移体是一类整合空间信息与特异性生化信息的信号细胞器，能够在形态发生等复杂生物学过程中协调迁移细胞的行为。