Supporting Information S1 - Young Offspring at Genetic Risk of Adult Psychoses: The Form of the Trajectory of IQ or Memory May Orient to the Right Dysfunction at the Right Time

This information suggests that the results presented in the main text did not depend on the chosen developmental age cut-offs. To allow the construction of a developmental trajectory, the offspring sample was divided into subsamples of different age. Since there is no empirical evidence on which to base the choice of age cut-offs, we chose cut-offs that correspond to developmental ages that may have a meaning in social, clinical and developmental psychopathology. Thus, in the text of our article, a four age-period was chosen, as follow: primary school years (age 7–12), young adolescence (13–16), late adolescence (17–19) and beginning of adulthood (20–22). When we re-examined the developmental patterns with three age periods (ages 7–14, 15–18, 19–22), the results remained congruent (Table S1). To further analyze the three period intervals, it can be noted that the Group variable was significant for all the cognitive functions tested. As in the “four period analysis”, there were no statistically significant Group x Age Periods interaction terms for the Global IQ and for the verbal memory tests. In contrast, for the two tests of visual memory, the interaction term showed a statistical trend (RCFTIR, p = .071; RCFTDR, p = .099; Table S1) with shapes of the trajectories similar to those of the four age periods i.e. a lagging period during childhood followed by a recuperation period from adolescence until adulthood (Figure S1), whereas Global IQ displayed again a stable deficit.
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本研究结果表明，正文呈现的结论并不依赖于所选定的发育年龄分界值。为构建发育轨迹，本研究将子代样本按年龄划分为不同子样本。鉴于尚无经验证据可作为年龄分界值选择的依据，我们选取了在社会、临床及发育精神病理学领域具备实际意义的发育年龄作为分界标准。据此，本文选取了四阶段年龄划分方案，具体如下：小学阶段（7~12岁）、青春早期（13~16岁）、青春晚期（17~19岁）以及成年早期（20~22岁）。当我们采用三阶段年龄划分（7~14岁、15~18岁、19~22岁）重新检验发育模式时，所得结果仍保持一致（补充表S1）。与“四阶段分析”结果一致，全量表智商（Global IQ）及言语记忆测验的组别×年龄阶段交互项均无统计学显著性。与之相反，两项视觉记忆测验的交互项呈现出统计学趋势（RCFTIR，p=0.071；RCFTDR，p=0.099；补充表S1），其轨迹形态与四阶段年龄划分结果相似：即儿童期存在发展滞后阶段，随后自青春期至成年期出现恢复阶段（补充图S1）；而全量表智商则再次表现出稳定的功能缺损。(DOC)