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This retrospective observational study included 269 CRRT sessions from 129 NS patients treated at Nanfang Hospital, Southern Medical University, from January 2019 to December 2022, it aim to investigate the efficacy and safety of LMWH combined with citrate anticoagulation in patients with NS requiring CRRT therapy, in order to find a better coagulation therapy with lower incidence of venous thrombosis and better filter lifespan.

本回顾性观察性研究纳入了2019年1月至2022年12月期间，在南方医科大学南方医院接受治疗的129例肾病综合征（Nephrotic Syndrome，NS）患者的269次连续性肾脏替代治疗（Continuous Renal Replacement Therapy，CRRT）疗程；本研究旨在探讨低分子肝素（Low Molecular Weight Heparin，LMWH）联合枸橼酸抗凝在需行CRRT治疗的NS患者中的有效性与安全性，以期寻获一种静脉血栓发生率更低、滤器使用寿命更长的更优抗凝治疗方案。