Mapping Immune Responses to CMV in Renal Transplantation

CMV is one of the most problematic pathogens in the immunocompromised host after solid organ and stem cell transplantation, increasing morbidity and mortality risk, and graft loss. Approaches for improved understanding and subsequent harnessing of the host immune response to CMV are needed to reduce the burden of CMV complications in immunocompromised individuals, including chronic injury of the transplanted organ.

CMV是实体器官移植与干细胞移植后免疫功能低下宿主中最棘手的病原体之一，可增加发病率、死亡率风险及移植物丢失率。亟需进一步深化对宿主抗CMV免疫反应的理解，并在此基础上开发利用该反应的策略，以减轻免疫功能低下个体的CMV并发症负担，包括移植器官的慢性损伤。