Percent parasite motility by various synthetic inhibitors and GSK-J4.

Parasites were treated with indicated compounds at 1 μM for 48 hours. All experiments were repeated at least three times n = 3. Except for MSU-TSR-6-104 which is a structurally inactive analog and MSU-TSR-6-38, all compounds are selective towards adult parasitic stages. The compounds are also active against the closely related B. pahangi and the rodent nematode L. sigmodontis. All reported percent inhibition are within a ≤ 10% standard error. All compounds are inactive against C. elegans at 100 μM.

将寄生虫以1 μM浓度的指定化合物处理48小时。所有实验均至少重复三次，n=3。除MSU-TSR-6-104（结构失活类似物）与MSU-TSR-6-38外，所有受试化合物均对成虫寄生阶段具有选择性。该类化合物对亲缘关系相近的马来布鲁线虫（B. pahangi）以及啮齿类线虫棉鼠丝虫（L. sigmodontis）同样具有活性。所有报道的抑制率百分比的标准误差均≤10%。所有受试化合物在100 μM浓度下对秀丽隐杆线虫（C. elegans）均无活性。