Open lung approach with low tidal volume mechanical ventilation attenuates lung injury in rats with massive brain damage

Conclusions: In BD, LVT/OLPEEP minimizes lung morpho-functional changes and inflammation compared to HVT/LPEEP. LVT/OLPEEP might represent a suitable ventilatory strategy in massive brain damage.结论：在脑损伤（Brain Damage, BD）患者中，与高潮气量/低水平呼气末正压（High Tidal Volume/Low Positive End-Expiratory Pressure, HVT/LPEEP）通气策略相比，低潮气量/开放肺呼气末正压（Low Tidal Volume/Open Lung Positive End-Expiratory Pressure, LVT/OLPEEP）可有效减轻肺的形态功能改变与炎症反应。低潮气量/开放肺呼气末正压或许可作为重型脑损伤患者的适宜机械通气策略。