Prevalence of hMLH1 and hMSH2 gene germline mutation in different family history and ethnicity.

*This type of population include American, European and Australian.@This indicates the number of studies have been included.#We categorized colorectal cancer patients who met the stringent Amsterdam criteria as Amsterdam-criteria positive group (AC+). Others have a strong family history but not strictly in conformity with Amsterdam criteria were defined as Amsterdam-criteria negative group (AC−).

此类受试人群涵盖美国、欧洲及澳大利亚籍个体。此为已纳入的研究数量。我们将满足严格阿姆斯特丹标准（Amsterdam Criteria）的结直肠癌患者归类为阿姆斯特丹标准阳性组（AC+）；将具有显著家族史但未严格符合阿姆斯特丹标准的患者定义为阿姆斯特丹标准阴性组（AC−）。