Hydroxyl-Directed Stereoselective Diboration of Alkenes

An alkoxide-catalyzed directed diboration
of alkenyl alcohols is
described. This reaction occurs in a stereoselective fashion and is
demonstrated with cyclic and acyclic homoallylic and bishomoallylic
alcohol substrates. After oxidation, the reaction generates 1,2-diols
such that the process represents a method for the stereoselective
directed dihydroxylation of alkenes.

本文报道了醇盐（alkoxide）催化的烯基醇定向双硼化反应。该反应以立体选择性方式进行，可应用于环状与非环状的高烯丙醇及双高烯丙醇类底物。经氧化后，该反应可生成1,2-二醇，因此该过程可作为烯烃的立体选择性定向二羟基化方法。