The Pediatric Template of Brain Perfusion (PTBP)

Magnetic resonance imaging (MRI) captures the dynamics of brain development with high spatial resolu- tion and with complementary modalities that quantify both brain structure and function. These measurements may yield valuable insights into the neural patterns that mark healthy maturation or that identify early risk for psychiatric disorder later in life. The Pediatric Template of Brain Perfusion (PTBP) is a free and public neuroimaging resource that will help accelerate the understanding of childhood brain development as seen through the lens of multiple modality neuroimaging and in relation to cognitive and environmental factors. The PTBP uses MRI to quantify cortex (T1), white matter (DTI), resting state functional connectivity (BOLD) and brain perfusion, as measured by Arterial Spin Labeling (ASL), in >100 children 7—17 years of age. The PTBP captures, within normally developing children and across several modalities, the trajectories that demarcate critical turning points in brain maturation. This novel resource allows a more detailed understanding of the structural and functional landmarks that are obtained during normal adolescent brain development. The full raw nifti dataset is available at the link below. The file jjperf.Rnw is the original knitr version of the article - no guarantee to compile "out of the box" nor to be consistent with the official final version of the manuscript which underwent revision outside of the knitr world. There are also several typos in this version. The PTBP was supported by Danny JJ Wang's R01MH080892 funded by NIMH. The article is in press.

磁共振成像（Magnetic resonance imaging, MRI）能够以高空间分辨率捕捉大脑发育的动态变化，并通过互补成像模态量化大脑结构与功能状态。此类测量可为揭示标志健康大脑成熟的神经模式，或是识别个体日后罹患精神疾病的早期风险提供宝贵见解。儿童脑灌注模板（Pediatric Template of Brain Perfusion, PTBP）是一款免费公开的神经影像资源，有助于通过多模态神经影像视角，并结合认知与环境相关因素，加速人们对儿童大脑发育的理解。PTBP针对100余名7至17岁的儿童，利用磁共振成像量化其皮层（T1加权成像）、白质（弥散张量成像, DTI）、静息态功能连接（血氧水平依赖成像, BOLD）以及通过动脉自旋标记（Arterial Spin Labeling, ASL）测得的脑灌注水平。PTBP能够覆盖多模态数据，捕捉正常发育儿童群体中标志大脑成熟关键转折点的发育轨迹；这一全新资源可帮助人们更细致地理解正常青少年大脑发育过程中出现的结构与功能特征节点。完整原始nifti格式数据集可通过下方链接获取。文件jjperf.Rnw为本文的原始knitr版本，无法保证其可直接开箱即用，也无法保证与经knitr外流程修订后的官方最终手稿版本一致，且该版本存在若干排版错误。PTBP的研究得到了美国国立精神卫生研究所（National Institute of Mental Health, NIMH）资助的R01MH080892项目（负责人为Danny JJ Wang）的支持。本文目前已录用待刊。