Long noncoding RNA profiling in hepatopancreas of white shrimp and its role in response to white spot syndrome virus infection

For years, Pacific white shrimp is one of marine species whichappears to be among the most commercialized species in marine aquaculture industryworldwide. Because of its importance on aquaculture industry andtrading value, shrimp aquaculture comes along with many concerns to farmers, such as shrimphealth, viability, growth, reproduction, and disease infection. White spot disease (WSD), inparticular, caused by white spot syndrome virus (WSSV), can spread very quickly in salinewaters and may lead to 100% shrimp mortality resulting in a massive loss to the farmers.Shrimp immunity, an important process involved in prevention and protection shrimp frompathogens, has been firstly studied. At present, it has been reported that the long noncodingRNAs (lncRNAs) play many regulatory function in biological processes as well as immunesystem in human and some other organisms. However, the role of lncRNAs in immune systemof white shrimp and its anti-viral activity remain unknown. Here, we aim to study how certainlncRNAs involve in immune system and exhibit its anti-viral activity upon WSSV infection.

多年来，凡纳滨对虾（Pacific white shrimp）是全球海水水产养殖业中商业化程度最高的养殖物种之一。鉴于其在水产养殖业中的重要地位与贸易价值，对虾养殖一直困扰着从业者，面临诸多核心关切：包括对虾健康、生存活力、生长发育、繁殖能力以及病害感染风险。其中尤以白斑综合征（WSD）危害最为严重，该病害由白斑综合征病毒（WSSV）引发，可在盐水环境中快速传播，能导致对虾100%死亡，给养殖户造成毁灭性经济损失。对虾免疫作为抵御病原体侵染、维持机体健康的核心生理过程，已得到先期研究。目前已有研究表明，长链非编码RNA（long noncoding RNAs, lncRNAs）在人类及其他部分生物的多种生命活动与免疫系统中发挥诸多调控功能。然而，长链非编码RNA在凡纳滨对虾免疫系统中的作用及其抗病毒活性仍有待阐明。本研究旨在探究特定长链非编码RNA如何参与凡纳滨对虾的免疫调控，并阐明其在白斑综合征病毒侵染过程中发挥的抗病毒活性机制。