Global miRNA expression in small bowel neuroendocrine tumors (SBNET) and their lymph node/liver metastases. Homo sapiens

miRNA profiling study revealing novel miRNAs deregulated in SBNET compared to normal small bowel and identifying miRNA that are differentially regulated with disease progression. These have the potential to be used in the future for patient stratification and treatment response monitoring. Overall design: Dataset 1 Matched samples from 15 SBNET patients (47 samples) were used to determine a miRNA profile for SBNET and identify potential markers of disease progression. Patient numbers: 1-15. Dataset 2 A second dataset of miRNA expression data (43 samples) containing an increased number of liver metastases, as well as SBNET and lymph node metastases. Patient numbers: B9-B140, controls: C1, C2.

本研究通过微小核糖核酸（miRNA）谱分析，对比正常小肠组织与小肠神经内分泌肿瘤（Small Bowel Neuroendocrine Tumors，SBNET）组织，筛选出SBNET中异常表达的新型miRNA，并鉴定出随疾病进程呈差异调控的miRNA。此类miRNA未来有望应用于患者分层及治疗响应监测。
整体实验设计：
数据集1：纳入15例SBNET患者的匹配样本（共计47份），用于构建SBNET的miRNA表达谱并筛选疾病进展相关潜在标志物，患者编号为1-15。
数据集2：包含第二组miRNA表达数据集（共43份样本），该队列涵盖更多肝转移灶、SBNET原发病灶及淋巴结转移灶样本，患者编号为B9-B140，对照样本为C1、C2。