Additional file 1: Table S1. of A database of human genes and a gene network involved in response to tick-borne encephalitis virus infection

Human genes/proteins (51) that had direct physical interactions with TBE viral particle, TBEV proteins or RNA. Table S2. Human genes (76) encoding mRNAs (or proteins) that were up- or down-regulated in response to TBEV infection. Table S3. Human genes (9) that possessed allelic variants associated with susceptibility or resistance to TBEV infection. Table S4. Human genes (6) encoding proteins that were required for inhibitory effect of other proteins against TBEV or attenuated its antiviral activity. Table S5. Human genes (6): knockout of these genes in mice increased mortality rates or effected the other clinical manifestations of the disease. Table S6. All genes from the catalog (140 genes). Table S7. Direct physical interactions (25) that were obtained from STRING and passed manual verification. Table S8. Genes/proteins from the catalog (41) that had one or more pairwise interactions with human genes/proteins within the network. (XLSX 151Â kb)

附表S2：与蜱传脑炎病毒（Tick-borne encephalitis virus, TBEV）颗粒、TBEV蛋白或RNA存在直接物理相互作用的人类基因/蛋白质，共51个。
附表S3：响应TBEV感染后mRNA（或蛋白质）表达上调或下调的编码基因，共76个。
附表S4：携带与TBEV感染易感性或抗性相关等位基因变异的人类基因，共9个。
附表S5：编码的蛋白质可参与其他蛋白对TBEV的抑制作用，或是可减弱该类蛋白抗病毒活性的人类基因，共6个。
附表S6：在小鼠体内敲除后可升高疾病死亡率或影响该疾病其他临床表现的人类基因，共6个。
附表S7：该基因目录下的全部基因，共140个。
附表S8：从STRING数据库（STRING）获取并经人工验证的直接物理相互作用，共25组。
该基因目录内的人类基因/蛋白质共41个，可在该互作网络中与其他人类基因/蛋白质存在至少一组两两相互作用。
（XLSX 151 KB）