Body weight, cortical area and lateral subchondral bone parameters in male mice.

Two-way ANOVA was used to assess the effects of surgery (control vs. surgery destabilizing the medial meniscus [DMM]) and genotype (Wnt16flox/flox vs. Cre-Wnt16flox/flox). The femoral cortical area was affected by genotype but not surgery, and no significant genotype by surgery interaction was detected. Body weight, lateral bone plate thickness, trabecular thickness and number was not affected by surgery, genotype or genotype by surgery interaction. BV/TV bone volume/tissue volume. Data are presented as mean ± SEM, P < 0.05 was considered statistically significant.

采用双因素方差分析（two-way ANOVA）评估手术（假手术组 vs 内侧半月板失稳手术[DMM]组）与基因型（Wnt16flox/flox与Cre-Wnt16flox/flox）的效应。股骨皮质骨面积受基因型影响而非手术因素，且未检测到基因型与手术的显著交互作用。体重、外侧骨板厚度、骨小梁厚度与骨小梁数量均不受手术、基因型或二者交互作用的影响。BV/TV即骨体积/组织体积。数据以平均值±标准误（SEM）表示，以P<0.05作为统计学显著性判定标准。