CDK2/CyclinE bound to compound 16 with P-loop in the EE conformation

CDK2/CyclinE bound to compound 16 with P-loop in the EE conformation Descriptor: (1R,3R)-3-{3-[(pyrazine-2-carbonyl)amino]-1H-pyrazol-5-yl}cyclopentyl [(1S)-1-cyclopropylethyl]carbamate, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 Authors: Baird, J, Holliday, M.J. Deposit date: 2025-04-22 Release date: 2025-04-30 Last modified: 2026-05-06 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Nanoscale Direct-to-Biology Optimization of Cdk2 Inhibitors. J.Med.Chem., 69, 2026本数据集为结合化合物16且P环处于EE构象的CDK2/细胞周期蛋白E（CyclinE）复合物。描述项：(1R,3R)-3-{3-[(吡嗪-2-甲酰基)氨基]-1H-吡唑-5-基}环戊基[(1S)-1-环丙基乙基]氨基甲酸酯、细胞周期蛋白依赖性激酶2（Cyclin-dependent kinase 2）、G1/S特异性细胞周期蛋白E1（G1/S-specific cyclin-E1）。作者：Baird, J、Holliday, M.J. 寄存日期：2025-04-22 发布日期：2025-04-30 最后修改日期：2026-05-06 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.98埃） 引用文献：《Cdk2抑制剂的纳米级直接生物学优化》，《药物化学杂志》，第69卷，2026