Effects of Clarithromycin and Amoxicillin on Gastric Emptying in Rats

The effects of oral administration of clarithromycin (CLR), amoxicillin (AMX), and lansoprazole (LPZ) on gastric emptying in rats were investigated by a glass powder method and a phenol red method. By both test methods, no significant effects on gastric emptying were observed when CLR, AMX, or LPZ was administered alone or when the three drugs were administered concomitantly. The levels of gastrointestinal absorption of [(14)C]CLR and [(14)C]AMX were measured. Four hours after injection of [(14)C]CLR or [(14)C]AMX into the stomach and duodenum loops of rats, 86.63 and 1.27% of the original amount of [(14)C]CLR administered were recovered in the contents of the stomach and duodenum loops, respectively, and 80.01 and 55.88% of the original amount of [(14)C]AMX administered were recovered in the contents of the stomach and duodenum loops, respectively.

本研究采用玻璃粉末法（glass powder method）与酚红法（phenol red method），探究了口服克拉霉素（clarithromycin, CLR）、阿莫西林（amoxicillin, AMX）及兰索拉唑（lansoprazole, LPZ）对大鼠胃排空的影响。两种检测方法的结果均显示，单独给予CLR、AMX或LPZ，或三者联合给药时，均未观察到对大鼠胃排空的显著影响。本研究同时测定了[¹⁴C]标记的克拉霉素（[¹⁴C]CLR）与阿莫西林（[¹⁴C]AMX）的胃肠道吸收水平。向大鼠胃及十二指肠环内注射[¹⁴C]CLR或[¹⁴C]AMX后4小时，给药初始剂量的[¹⁴C]CLR在胃内容物与十二指肠环内容物中的回收率分别为86.63%与1.27%；给药初始剂量的[¹⁴C]AMX的回收率则分别为80.01%与55.88%。