Whole Transcriptome RNA-seq in Brain Tissue of Young and Old Peromyscus maniculatus and P. leucopus. Whole Transcriptome RNA-seq in Brain Tissue of Young and Old Peromyscus maniculatus and P. leucopus

Whole transcriptome RNA sequencing in brain tissue was generated to explore differences between young and old animals of two closely related species of deer mice (genus Peromyscus) that reportedly differ in their lifespans: P. leucopus that lives for up to 8 years and P. maniculatus that exhibits a lifespan of about 4 years. Overall design: Brain mRNA profiles of young (n=6) and old (n=6) P. maniculatus and P. leucopus.

本研究通过对脑组织开展全转录组RNA测序（Whole transcriptome RNA sequencing），旨在探究两种亲缘关系相近、据报道寿命存在差异的鹿鼠属（Peromyscus）物种的年轻与老年个体间的转录组差异：其中白足鹿鼠（P. leucopus）的最长寿命可达8年，而鹿鼠（P. maniculatus）的寿命约为4年。实验整体设计：针对年轻（n=6）与老年（n=6）的鹿鼠及白足鹿鼠的脑组织mRNA表达谱进行分析。