GDSC2

GDSC2 PharmacoSet (PSet) generated by ORCESTRA. Metadata can be found on ORCESTRA at: http://orcestra.ca/pset/10.5281/zenodo.5787145 Disclaimer The GDSC2 data have been generated and shared by the Wellcome Trust Sanger Institute as part of the Genomics of Drug Sensitivity in Cancer (GDSC) Programme. The Haibe-Kains Lab has reprocessed and re-annotated the data to maximize overlap with other pharmacogenomic datasets. Data Usage Policy Users have a non-exclusive, non-transferable right to use data files for internal proprietary research and educational purposes, including target, biomarker and drug discovery. Excluded from this licence are use of the data (in whole or any significant part) for resale either alone or in combination with additional data/product offerings, or for provision of commercial services. Please note: The data files are experimental and academic in nature and are not licensed or certified by any regulatory body. Genome Research Limited provides access to data files on an “as is” basis and excludes all warranties of any kind (express or implied). If you are interested in incorporating results or software into a product, or have questions, please contact [e-mail]. Source: https://depmap.sanger.ac.uk/documentation/data-usage-policy/ Sanger's terms and conditions: http://www.cancerrxgene.org/legal Please cite the following when using these data Iorio F, Knijnenburg TA, Vis DJ, Bignell GR, Menden MP, Schubert M, Aben N, Gonçalves E, Barthorpe S, Lightfoot H, Cokelaer T, Greninger P, van Dyk E, Chang H, de Silva H, Heyn H, Deng X, Egan RK, Liu Q, Mironenko T, Mitropoulos X, Richardson L, Wang J, Zhang T, Moran S, Sayols S, Soleimani M, Tamborero D, Lopez-Bigas N, Ross-Macdonald P, Esteller M, Gray NS, Haber DA, Stratton MR, Benes CH, Wessels LFA, Saez-Rodriguez J, McDermott U, Garnett MJ. A Landscape of Pharmacogenomic Interactions in Cancer. Cell. 2016 Jul 28;166(3):740-754. doi: 10.1016/j.cell.2016.06.017. Epub 2016 Jul 7. PMID: 27397505; PMCID: PMC4967469. Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, Bindal N, Beare D, Smith JA, Thompson IR, Ramaswamy S, Futreal PA, Haber DA, Stratton MR, Benes C, McDermott U, Garnett MJ. Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res. 2013 Jan;41(Database issue):D955-61. doi: 10.1093/nar/gks1111. Epub 2012 Nov 23. PMID: 23180760; PMCID: PMC3531057. Picco G, Chen ED, Alonso LG, Behan FM, Gonçalves E, Bignell G, Matchan A, Fu B, Banerjee R, Anderson E, Butler A, Benes CH, McDermott U, Dow D, Iorio F, Stronach E, Yang F, Yusa K, Saez-Rodriguez J, Garnett MJ. Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening. Nat Commun. 2019 May 16;10(1):2198. doi: 10.1038/s41467-019-09940-1. PMID: 31097696; PMCID: PMC6522557.

GDSC2药物组数据集（PharmacoSet, PSet）由ORCESTRA生成。其元数据可于ORCESTRA平台的以下链接查阅：http://orcestra.ca/pset/10.5281/zenodo.5787145

免责声明
本GDSC2数据集由威康桑格研究所（Wellcome Trust Sanger Institute）作为癌症药物敏感性基因组学（Genomics of Drug Sensitivity in Cancer, GDSC）项目的一部分生成并共享。Haibe-Kains实验室对该数据集进行了重新处理与注释，以最大化其与其他药物基因组学数据集的重叠度。

数据使用政策
用户享有非排他性、不可转让的使用权，可将数据文件用于内部专有研究与教育用途，包括靶点、生物标志物及药物发现相关研究。本许可禁止以下使用行为：将数据（全部或重要部分）单独或与其他数据/产品组合后转售，或将其用于提供商业服务。

请注意：本数据文件属于实验性与学术性资料，未经过任何监管机构的许可或认证。基因组研究有限公司（Genome Research Limited）按现状提供数据文件，并排除所有明示或默示的担保责任。若您有意将本数据集的结果或软件整合至产品中，或有相关疑问，请联系[e-mail]。

来源：https://depmap.sanger.ac.uk/documentation/data-usage-policy/
桑格研究所条款与条件：http://www.cancerrxgene.org/legal

使用本数据集时，请引用以下文献：
1. Iorio F, Knijnenburg TA, Vis DJ, Bignell GR, Menden MP, Schubert M, Aben N, Gonçalves E, Barthorpe S, Lightfoot H, Cokelaer T, Greninger P, van Dyk E, Chang H, de Silva H, Heyn H, Deng X, Egan RK, Liu Q, Mironenko T, Mitropoulos X, Richardson L, Wang J, Zhang T, Moran S, Sayols S, Soleimani M, Tamborero D, Lopez-Bigas N, Ross-Macdonald P, Esteller M, Gray NS, Haber DA, Stratton MR, Benes CH, Wessels LFA, Saez-Rodriguez J, McDermott U, Garnett MJ. 癌症中药物基因组相互作用的全景图谱. 《细胞》（Cell）. 2016年7月28日;166(3):740-754. DOI: 10.1016/j.cell.2016.06.017. 2016年7月7日在线发表. PMID: 27397505; PMCID: PMC4967469.
2. Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, Bindal N, Beare D, Smith JA, Thompson IR, Ramaswamy S, Futreal PA, Haber DA, Stratton MR, Benes C, McDermott U, Garnett MJ. 癌症药物敏感性基因组学（GDSC）：用于癌细胞治疗性生物标志物发现的资源库. 《核酸研究》（Nucleic Acids Research）. 2013年1月;41(数据库特刊):D955-61. DOI: 10.1093/nar/gks1111. 2012年11月23日在线发表. PMID: 23180760; PMCID: PMC3531057.
3. Picco G, Chen ED, Alonso LG, Behan FM, Gonçalves E, Bignell G, Matchan A, Fu B, Banerjee R, Anderson E, Butler A, Benes CH, McDermott U, Dow D, Iorio F, Stronach E, Yang F, Yusa K, Saez-Rodriguez J, Garnett MJ. 基于药理学与CRISPR-Cas9筛选评估基因融合与癌细胞适应性的功能关联. 《自然-通讯》（Nature Communications）. 2019年5月16日;10(1):2198. DOI: 10.1038/s41467-019-09940-1. PMID: 31097696; PMCID: PMC6522557.

搜集汇总

背景与挑战

背景概述

GDSC2数据集是一个专注于癌症药物敏感性研究的资源，由Wellcome Trust Sanger Institute生成并由Haibe-Kains Lab重新处理，旨在促进癌症治疗靶点和生物标志物的发现。数据集包含详细的药物敏感性数据，适用于学术研究和教育用途，但不允许用于商业目的。