Palladium-Catalyzed Cascade Reactions of Isocyanides with Enaminones: Synthesis of 4‑Aminoquinoline Derivatives

A method
for palladium-catalyzed cascade reactions of isocyanides
with enaminones has been developed. This methodology provides a direct
approach to 4-aminoquinoline derivatives under mild conditions with
up to 98% yields.

本研究开发了一种钯催化（palladium-catalyzed）的异氰类化合物（isocyanides）与烯胺酮（enaminones）的级联反应（cascade reactions）方法。该方法可在温和反应条件下直接合成4-氨基喹啉衍生物（4-aminoquinoline derivatives），最高收率可达98%。