Additional file 6 of Ceftiofur treatment of sows results in long-term alterations in the nasal microbiota of the offspring that can be ameliorated by inoculation of nasal colonizers

Additional file 6. Figure S2. Heatmap representing the top 25 species by average abundance with Bray Curtis coefficient (A and C) and top 25 pathways by average abundance by Spearman correlation coefficient (B and D). Pregnant sows were treated with ceftiofur or remained untreated. A group of piglets born to treated sows remained nontreated (TS group), while piglets born to non-treated sows were treated with ceftiofur (TP group). A group of piglets were inoculated with selected colonizers of the upper respiratory tract either born to ceftiofur-treated sows (TS-IP) and to non-treated sows (IP group). As control, piglets born to non-treated sows remained non-treated. Groups TS, TP and control groups are compared in panels A and B. Groups IP, TS-IP and control are compared in panels C and D.

补充材料6 图S2。本热图分别展示了基于平均丰度排序的前25个物种（采用布雷-柯蒂斯（Bray Curtis）系数，对应子图A与C），以及基于平均丰度排序的前25条通路（采用斯皮尔曼相关系数，对应子图B与D）。实验中妊娠母猪分为两组：一组经头孢噻呋（ceftiofur）处理，另一组不予处理。衍生的仔猪分组如下：由经处理母猪所产且未接受额外处理的仔猪为TS组；由未处理母猪所产且经头孢噻呋处理的仔猪为TP组。另有两组仔猪：一组由经头孢噻呋处理的母猪所产（TS-IP组），另一组由未处理母猪所产（IP组），两组均接种选定的上呼吸道定植菌。以未处理母猪所产且未接受任何处理的仔猪作为对照组。子图A与B比较TS组、TP组与对照组；子图C与D比较IP组、TS-IP组与对照组。