I50V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor

I50V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor Descriptor: 4,4'-{(3S,4S)-PYRROLIDINE-3,4-DIYLBIS[(BENZYLIMINO)SULFONYL]}DIBENZAMIDE, CHLORIDE ION, Protease Authors: Boettcher, J, Blum, A, Heine, A, Diederich, W.E, Klebe, G. Deposit date: 2007-08-30 Release date: 2008-09-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural and Kinetic Analysis of Pyrrolidine-Based Inhibitors of the Drug-Resistant Ile84Val Mutant of HIV-1 Protease J.Mol.Biol., 383, 2008

I50V型HIV-1蛋白酶（HIV-1 protease）突变体与经氨基甲酰基修饰的吡咯烷类抑制剂形成的复合物。描述符：4,4'-{(3S,4S)-吡咯烷-3,4-二基双[(苄基亚氨基)磺酰]}二苯甲酰胺、氯离子、蛋白酶。作者：Boettcher, J.、Blum, A.、Heine, A.、Diederich, W. E.、Klebe, G.。沉积日期：2007-08-30。发布日期：2008-09-02。最后修改日期：2023-08-30。实验方法：X射线衍射（分辨率1.8埃）。引用文献：《抗药性HIV-1蛋白酶Ile84Val突变体的吡咯烷类抑制剂的结构与动力学分析》，《Journal of Molecular Biology》（J.Mol.Biol.），第383卷，2008年。