Gut microbiota and colonic gene expression: a lignan trial in humans. Homo sapiens

Intake of foods high in dietary fiber is associated with lower risk of colorectal cancer. Gut bacteria convert constituents of plant foods, sugh as lignans and dietary fiber, to biologically active compounds that in animal models prevent the development of colon cancer. In a human dietary intervention, we will study how these biologically active compounds affect colon cell-signaling pathways important to colorectal cancer risk.

高膳食纤维（dietary fiber）食物的摄入与结直肠癌（colorectal cancer）发病风险降低显著相关。肠道菌群可将植物性食物的各类成分，例如木脂素（lignans）与膳食纤维，转化为具有生物活性的化合物，这类化合物在动物模型中可抑制结肠癌（colon cancer）的发生与发展。在一项人体膳食干预研究中，我们将探究这类生物活性化合物如何影响与结直肠癌发病风险密切相关的结肠细胞信号通路。