Raw data (behavior data) for Generation of stable heading representations in diverse visual scenes

Raw behavior data of all flies for the following paper.Generation of stable heading representations in diverse visual scenesSung Soo Kim+, Ann M. Hermundstad, Sandro Romani, L. F. Abbott, Vivek Jayaraman+Nature (2019) 576:126-131Many animals rely on an internal heading representation when navigating in varied environments. How this representation is linked to the sensory cues that define different surroundings is unclear. In the fly brain, heading is represented by 'compass' neurons that innervate a ring-shaped structure known as the ellipsoid body. Each compass neuron receives inputs from 'ring' neurons that are selective for particular visual features; this combination provides an ideal substrate for the extraction of directional information from a visual scene. Here we combine two-photon calcium imaging and optogenetics in tethered flying flies with circuit modelling, and show how the correlated activity of compass and visual neurons drives plasticity, which flexibly transforms two-dimensional visual cues into a stable heading representation. We also describe how this plasticity enables the fly to convert a partial heading representation, established from orienting within part of a novel setting, into a complete heading representation. Our results provide mechanistic insight into the memory-related computations that are essential for flexible navigation in varied surroundings.Additional materials found in this Collection: https://doi.org/10.25378/janelia.c.4932540

本数据集收录了下述论文中所有果蝇的原始行为数据：《多样视觉场景下稳定航向表征的构建》（*Generation of stable heading representations in diverse visual scenes*），作者为Sung Soo Kim+、Ann M. Hermundstad、Sandro Romani、L. F. Abbott、Vivek Jayaraman+，发表于《自然》（*Nature*）(2019) 576:126-131。
许多动物在复杂环境中导航时，依赖于内部的航向表征。目前学界尚未明确该表征与定义不同环境的感觉线索之间的关联机制。在果蝇脑中，航向由投射至椭圆体（ellipsoid body）这一环形结构的罗盘神经元（compass neuron）所表征。每一类罗盘神经元接收对特定视觉特征具有选择性的环形神经元（ring neuron）的输入，这一连接为从视觉场景中提取方向信息提供了理想的神经底物。本研究将束缚飞行果蝇的双光子钙成像（two-photon calcium imaging）、光遗传学（optogenetics）技术与环路建模（circuit modelling）相结合，揭示了罗盘神经元与视觉神经元的协同活动如何驱动神经可塑性，进而将二维视觉线索灵活转化为稳定的航向表征。此外，本研究还阐明了该可塑性如何帮助果蝇将在新环境局部区域定向时建立的部分航向表征，转换为完整的航向表征。本研究结果为复杂环境下灵活导航所必需的记忆相关计算机制提供了深入的机制性见解。
本数据集集中的补充材料可通过以下链接获取：https://doi.org/10.25378/janelia.c.4932540