normal human CFTR overexpression in mouse lung. Mus musculus

Identification of Genes Responsive to the Expression of Normal Human CFTR Keywords: genotype comparison Overall design: To discern the effects of increased expression of normal human CFTR, lung mRNA levels were assessed in mice expressing the normal human CFTR cDNA under control of the Sftpc gene promoter in respiratory epithelial cells of adult mice. Triplicate samples from SP-C-hCFTRtg/tg, SP-C-hCFTRtg/-, and wild type mice were compared.

正常人类囊性纤维化跨膜传导调节因子（CFTR）表达应答基因的鉴定
关键词：基因型比较
整体实验设计：为阐明正常人类CFTR表达上调所产生的生物学效应，本研究对成年小鼠呼吸上皮细胞中受Sftpc基因启动子调控、表达正常人类CFTR cDNA的小鼠的肺组织mRNA水平进行了检测，并对SP-C-hCFTRtg/tg、SP-C-hCFTRtg/-及野生型小鼠的三份重复样本开展了比对分析。