Comparative transcriptomic profiles in U-BIOPRED and Australian Newcastle severe asthma cohorts [sputum]. Comparative transcriptomic profiles in U-BIOPRED and Australian Newcastle severe asthma cohorts [sputum]

Severe asthma is a heterogeneous disease. Transcriptomic analysis contributes to understanding the driver mechanisms necessary for developing new therapies. The aim of this study was to identify mechanistic pathways of severe asthma across two independent cohorts. Overall design: This cross-sectional study examined transcriptomic data from endobronchial biopsies (n=73) and induced sputum (n=44) in an Australian Newcastle severe asthma cohort and the U-BIOPRED cohort.

重症哮喘是一种异质性疾病。转录组学分析有助于阐明开发新型治疗手段所需的致病驱动机制。本研究旨在针对两个独立队列（cohort），明确重症哮喘的致病通路。研究设计：本横断面（cross-sectional）研究分析了澳大利亚纽卡斯尔重症哮喘队列与U-BIOPRED队列的转录组数据，涉及支气管内膜活检（endobronchial biopsies）样本（n=73）与诱导痰（induced sputum）样本（n=44）。