ConcePTION WP3 task 3.3. Quantification of amoxicillin in milk and blood collected from lactating sows and in piglets’ blood

The dataset contains data about amoxicillin quantification in milk and blood collected from lactating sows and in piglets’ blood, obtained in the framework of the Horizon 2020 IMI funded project ConcePTION. The main goal of ConcePTION is to establish a trusted ecosystem that can efficiently, systematically, and in an ethically responsible manner, generate and disseminate reliable evidence-based information regarding effects of medications used during pregnancy and breastfeeding to women and their healthcare providers. This will be achieved by generating, cataloguing, linking, collecting and analysing data from pharmacovigilance, modelling, routine healthcare, breastmilk samples through a large network. Within such framework, task 3.3 of WP3 aims at developing and characterising a relevant in vivo model for drug passage from maternal blood to human breast milk. Based on a preliminary scan of existing literature, the chosen species to perform such non-clinical trial was the porcine one due to high anatomical and physiological similarities. In the initial trial, amoxicillin was chosen as the first molecule for a variety of reasons including alignment with other Work Packages (WPs) performing studies on human breastmilk. Additionally, since amoxicillin is commonly used in pigs, the choice of the route of administration, the administration interval and the doses were supported by reliable background data.

本数据集收录了泌乳母猪乳汁、血液以及仔猪血液中的阿莫西林定量检测数据，相关数据来源于欧盟地平线2020（Horizon 2020）创新药物倡议（IMI）资助的ConcePTION项目。ConcePTION项目的核心目标是构建一个可信生态系统，能够以高效、系统且符合伦理规范的方式，生成并传播关于妊娠及哺乳期用药对女性及其医疗服务提供者的可靠循证信息。该目标将通过大型网络平台，采集、编目、关联、收集并分析来自药物警戒、建模、常规医疗以及母乳样本的相关数据来实现。在此框架下，第3工作包（WP3）的3.3任务旨在开发并表征一种用于研究药物从母体血液向人母乳转运的相关体内模型。基于对现有文献的初步调研，由于猪在解剖学与生理学上与人类高度相似，因此选择猪作为该非临床试验的受试物种。在初步试验中，选择阿莫西林作为首个受试药物的原因众多，其中包括与其他针对人母乳开展研究的工作包（WPs）保持研究方向一致。此外，由于阿莫西林在生猪养殖中应用广泛，给药途径、给药间隔与给药剂量的选择均有可靠的背景数据支撑。